Document Type : Research Paper


1 Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

2 Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.



The use of nanoparticles in the hyperthermia method is very effective due to their small size to penetrate the cancer cell and better control and uniform temperature distribution. Cobalt nanoparticles are a good option in hyperthermia due to their saturated momentum and excellent magnetic properties. On the other hand, to minimize the cytotoxicity of cobalt nanoparticles and improve hyperthermia, it is necessary to use cobalt nanoparticles in composite form with other materials. For this purpose, in the present study, reduced cobalt-reduced cobalt (rGO-Co) composite nanoparticles were synthesized for use in heat treatment by the co-precipitation method. The synthesized powders were characterized by FESEM, TEM, XRD, VSM, and DSC-TGA tests, and the MTT test was used to determine biocompatibility, and hyperthermia test was used to determine the specific adsorption rate of the material. The results of the hyperthermia test showed a higher specific adsorption rate of rGO-Co composite nanoparticles than graphene oxide and cobalt nanoparticles. The study of the biological behavior of rGO-Co composite nanoparticles at concentrations of 30-100 μg/ml showed good biocompatibility of rGO-Co composite nanoparticles in comparison with cobalt nanoparticles. Fibroblasts grew and proliferated well at concentrations of 30 and 50 μg/ml.


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